However, as each healthy individual carries approximately 10,000 such variants, hundreds of them are singletons, it is still challenging to correctly identify pathogenic causal variants from benign and non-functional ones in the coding regions. Amino acid changing variants are probably the most well-studied candidate variant type for pathogenic variants. The issue is especially prominent when the phenotype of interest has low prevalence, such as rare Mendelian disorders where only the proband’s and the parents’ genetic testing data are available. This issue is prominent for rare genetic variants (allele frequency <1%) since traditional methods, such as population-based genome-wide association and whole-exome sequencing studies, lack the power to identify rare pathogenic or causal variants from rare benign variants. However, our current ability to detect genetic variants far exceeds our ability to interpret them, which is one of the significant gaps in effectively utilizing NGS data. Next-generation sequencing (NGS) has dramatically improved our ability to detect genetic variants in the human genome.
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Supplemental provisions or clauses published in agency acquisition regulations shall be numbered in the same manner in which FAR provisions and clauses are numbered except that. (ii) Supplemental provisions or clauses published in agency acquisition regulations shall be in full text and the prescription for the use of each shall be included. (C) Developed for use at a suborganizational level of an agency, not meant for repetitive use, but intended to meet the needs of an individual acquisition and, thus, impractical to include in either an agency or suborganization acquisition regulation. (B) Prescribed and included in a regulation issued by a suborganization of an agency to satisfy the needs of that particular suborganization or (A) Prescribed and included in authorized agency acquisition regulations issued within an agency to satisfy the specific needs of the agency as a whole (i) Provisions or clauses that supplement the FAR are. (2) Provisions or clauses that supplement the FAR. The following example illustrates the makeup of the FAR provision or clause number (see Figure 1 below). The FAR provision or clause number is then completed by a hyphen and a sequential number assigned within each section of subpart 52.2. The next two digits of the provision or clause number correspond to the number of the FAR subject part in which the provision or clause is prescribed. All FAR provision and clause numbers begin with "52.2," since the text of all FAR provisions and clauses appear in subpart 52.2. Each FAR provision or clause is uniquely identified. The subpart is arranged by subject matter, in the same order as, and keyed to, the parts of the FAR. subpart 52.2 sets forth the text of all FAR provisions and clauses, each in its own separate subsection. "Modification," as used in this subpart, means a minor change in the details of a provision or clause that is specifically authorized by the FAR and does not alter the substance of the provision or clause (see 52.104). 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